Detailed view for Bm1_00275

Basic information

TDR Targets ID: 242182
Brugia malayi, S-phase kinase-associated protein SKR-1
Source Database / ID:  GenBank

pI: 4.2151 | Length (AA): 168 | MW (Da): 19264 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01466   Skp1 family, dimerisation domain
PF03931   Skp1 family, tetramerisation domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0006511   ubiquitin-dependent protein catabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 167 2ast (A) 1003 1155 76.00 0 1 1.72908 -1.1
10 167 3ogk (A) 5 153 62.00 0 1 1.61308 -1
10 167 2ast (A) 1003 1155 76.00 0 1 1.72978 -1.12
10 167 3ogk (A) 5 153 62.00 0 1 1.60848 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127430)

Species Accession Gene Product
Arabidopsis thaliana AT3G60010   SKP1-like protein 13
Arabidopsis thaliana AT4G34470   SKP1-like protein 12
Arabidopsis thaliana AT4G34210   SKP1-like protein 11
Arabidopsis thaliana AT5G42190   SKP1-like protein 1B
Arabidopsis thaliana AT1G75950   S-phase kinase-associated protein 1
Babesia bovis BBOV_IV006860   cytosolic glycoprotein FP21, putative
Brugia malayi Bm1_00275   S-phase kinase-associated protein SKR-1
Candida albicans CaO19.4427   kinetochore complex
Candida albicans CaO19.11905   kinetochore complex
Caenorhabditis elegans CELE_F46A9.4   Protein SKR-2
Caenorhabditis elegans CELE_F46A9.5   Protein SKR-1
Cryptosporidium parvum cgd7_2500   Skp1 family protein, putative
Dictyostelium discoideum DDB_G0273615   cytosolic glycoprotein FP21
Dictyostelium discoideum DDB_G0269230   cytosolic glycoprotein FP21
Dictyostelium discoideum DDB_G0273251   cytosolic glycoprotein FP21
Drosophila melanogaster Dmel_CG12227   CG12227 gene product from transcript CG12227-RA
Drosophila melanogaster Dmel_CG43089   CG43089 gene product from transcript CG43089-RC
Drosophila melanogaster Dmel_CG16983   CG16983 gene product from transcript CG16983-RD
Echinococcus granulosus EgrG_000965900   S phase kinase associated protein SKR 1
Echinococcus granulosus EgrG_000965600   S phase kinase associated protein 1
Entamoeba histolytica EHI_118670   Skp1 family protein
Echinococcus multilocularis EmuJ_000965900   S phase kinase associated protein SKR 1
Echinococcus multilocularis EmuJ_000965600   S phase kinase associated protein 1
Homo sapiens 6500   S-phase kinase-associated protein 1
Leishmania braziliensis LbrM.11.0950   S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2- associated protein
Leishmania donovani LdBPK_111200.1   SKP1-like protein
Leishmania infantum LinJ.11.1200   S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2- associated protein
Leishmania major LmjF.11.1210   S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2- associated protein
Leishmania mexicana LmxM.11.1210   S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2- associated protein
Loa Loa (eye worm) LOAG_02338   S-phase kinase-associated protein SKR-1
Mus musculus ENSMUSG00000036309   S-phase kinase-associated protein 1A
Neospora caninum NCLIV_002630   Protein F46A9.4, confirmed by transcript evidence, related
Oryza sativa 4345419   Os08g0375700
Oryza sativa 4347721   Os09g0539500
Oryza sativa 9270098   Os11g0456300
Oryza sativa 4346586   Os09g0273800
Oryza sativa 9267738   Os02g0101550
Onchocerca volvulus OVOC9486  
Plasmodium berghei PBANKA_1142900   suppressor of kinetochore protein 1, putative
Plasmodium falciparum PF3D7_1367000   suppressor of kinetochore protein 1, putative
Plasmodium knowlesi PKNH_1104200   suppressor of kinetochore protein 1, putative
Plasmodium vivax PVX_115310   suppressor of kinetochore protein 1, putative
Plasmodium yoelii PY00081   skp1
Saccharomyces cerevisiae YDR328C   SCF ubiquitin ligase subunit SKP1
Schistosoma japonicum Sjp_0208540   ko:K03094 S-phase kinase-associated protein 1, putative
Schistosoma mansoni Smp_052910   skp1-related
Trypanosoma brucei gambiense Tbg972.11.6910   S-phase kinase-associated protein, putative,Skp1 family protein, putative,Cyclin A/CDK2-associated protein
Trypanosoma brucei Tb927.11.6130   SKP1-like protein
Trypanosoma congolense TcIL3000.11.6650   SKP1-like protein
Trypanosoma congolense TcIL3000.11.6670   SKP1-like protein
Trypanosoma cruzi TcCLB.508041.10   SKP1-like protein
Trypanosoma cruzi TcCLB.506297.350   SKP1-like protein
Toxoplasma gondii TGME49_207680   suppressor of kinetochore protein 1, putative
Theileria parva TP03_0225   Skp1 protein, putative
Trichomonas vaginalis TVAG_098740   conserved hypothetical protein

Essentiality

Bm1_00275 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3990 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3990 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.3990 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.3990 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F46A9.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F46A9.5 Caenorhabditis elegans larval arrest wormbase
CELE_F46A9.5 Caenorhabditis elegans larval lethal wormbase
CELE_F46A9.5 Caenorhabditis elegans slow growth wormbase
CELE_F46A9.5 Caenorhabditis elegans sterile wormbase
CELE_F46A9.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_F46A9.4 Caenorhabditis elegans larval arrest wormbase
CELE_F46A9.4 Caenorhabditis elegans slow growth wormbase
CELE_F46A9.4 Caenorhabditis elegans sterile wormbase
YDR328C Saccharomyces cerevisiae inviable yeastgenome
TGME49_207680 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00275 (Brugia malayi), S-phase kinase-associated protein SKR-1
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